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KMID : 0385219990090010070
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Korean Journal of Gerontology
1999 Volume.9 No. 1 p.70 ~ p.77
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The Effects of Opuntia ficus-indica Fruit Powder on Antioxidant Parameters in Senescence-Accelerated Mouse(SAM)
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Baek Seong-Kyu
Kim Hee-Yeon
Yang Seung-Don
Song Chang-Woo
Shin Tae-Kyun
Han Sang-Seop
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Abstract
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Aging is proposed to be caused by cell mediated oxidation of free radicals, and aging process is believed to be slowed down by several antioxidative biochemicals and enzymes such as glutathione, catalase and superoxide dismutase(SOD). We studied the effects of Opuntia ficus-indica Frult Powder(OFP) treatment on the activities of these antioxidative factors and on memory capacity in senescence-accelerated prone mouse (SAMP8), which has been proven to be a useful animal model of age-related learning and memory disorders, and in senescence-accelerated resistant mouse(SAMR1). The main constituent of OFP is poly-phenol compounds which remove free radicals. In this study, in order to test anti-aging effects of OFP on aging model animal, OFP(1.2 g/kg/day) was orally administered to 7 months old SAM for 30 days. The effects on the memory capacity as behavioral parameter was examined by passive avoidance test. No significant difference was found between OFPtreated groups and their control groups in both SAMP8 and SAMR1 in passive avoidance test. The degree of lipid peroxidation, hepatic contents of glutathione, activities of catalase and SOD in hepatic extracts of SAMP8 and SAMR1 mice were analysed. In SAMP8 mice, lipid peroxidation content was decreased in OFP treatment group compared to its control group (P<0.05). Glutathione content was significantly increased in OFP treatment group in both SAMP8(P<0.0001) and SAMR1(P<0.05). Catalase activity was significantly increased in treatment group of SAMR1, while no significant difference of SOD activity was found. Our results indicate that the treatment of OFP increases antioxidant activities in mouse liver. Accordingly, we suppose that OFP may play a role in anti-aging.
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KEYWORD
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Aging, Opuntia ficus-indica, Senescence-accelerated mouse(SAM), Passive avoidance test, Antioxidant
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